Indou Dème LY, Mame Sokhna GUEYE , Aïssatou BA, Ibrahima DIAGNE, Tandakha N. DIEYE
Introduction: The Wiskott Aldrich syndrome (WAS) is a X-linked genetic disease. It is due to a mutation of the WASP gene that regulates the actin cytoskeleton. It is characterized by a clinical triad that combines immune deficiency, eczema and bleeding due to microcytic thrombocytopenia. Immunodeficiency manifests itself by the occurrence of recurrent and / or severe infections, autoimmunity or malignancy.
Rasha H El-Owaidy, MD, PhD; lecturer of Pediatrics and Clinical Immunology. Faculty of Medicine, Ain Shams University, Cairo, Egypt
Introduction:Hyper immunoglobulin M (HIGM) syndrome results from a variety of genetic defects that affect the interaction between T-lymphocytes and B-lymphocytes leading to inability to switch from the production of antibodies of the IgM type to antibodies of the IgG, IgA or IgE types.
Rasha H El-Owaidy, MD, PhD; Pediatrics and Clinical Immunology, Faculty of Medicine, Ain Shams University, Caire, Egypte
Traduit par Jeddane Leïla, PhD, Maroc
Introduction: Le syndrome Hyper-immunoglobuline M (HIGM) résulte d’une variété de defaults génétiques qui affectent l’interaction entre les lymphocytes T et B aboutissant à l’incapacité, par ces derniers, de ‘switcher’ de la production d’anticorps d’isotype IgM vers les isotypes IgG, IgA ou IgE.
Yousif Abdalla, Idriss Matoug, Hanan Alsalheen. Children's Hospital, Faculty of Medicine, Benghazi University, Benghazi, Libya.
Agammaglobulinemia is a primary immunodeficiency disease. Affected children presented a blockade in maturation of B-cells in the bone marrow which leads to low or absent serum immunoglobulin levels (1). There are three types: X-linked, early onset, and late onset.